NCT06650345

Aerobic Exercise Effects on Cognitive Function in Aging Individuals

Exploring the Impact of Supervised Treadmill Aerobic Exercise on Cognitive Function and Apoptotic-Related Biomarkers in Aging Individuals

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: King Saud University · Academic / Other
• Sex: All
• Age: 65 Years – 95 Years
• Healthy volunteers: Accepted

Summary

Positive effects are exerted by participating in moderate exercise training with physical activity which positively affects body health, including cognitive abilities, among older adults. Thus, the investigators are trying to study the potential effects of the supervised aerobic training regimen for 12 weeks on cognitive function among older adults based on molecular changes in cellular apoptosis.

Detailed description

Physical activity exerts many positive effects on body health, including cognitive abilities, among older adults. Nevertheless, a paucity of knowledge exists regarding the potential anti-apoptotic benefits of moderate exercise and its potential influence on cognitive function. The objective of the present study was to explore the possible connection between the anti-apoptotic mechanisms associated with exercise and cognitive performance in a cohort of 60 older adults who participated in a 12-week supervised aerobic training regimen. A total of 120 healthy home residents and older subjects with an age range of 65 to 95 years were enrolled to participate in this study. Only, 60 subjects who met the inclusion criteria were included in this study. The participants were categorized into two groups, specifically the control group (consisting of 30 individuals) and the exercise group (also comprising 30 individuals), based on their participation in an exercise program. Assessments of cognitive function, leisure-time physical activity (LTPA), and apoptotic-related markers such as Bcl-2, p53, and Cytochrome c were conducted both before and after a 12-week aerobic exercise intervention.

Conditions

• Cognitive Function
• Exercise Training

Interventions

Type	Name	Description
OTHER	supervised aerobic exercise	In this training program, the participants exercised for 45-60 minutes through intervals on a treadmill, bike, or stair climber, three times a week for 12 weeks.

Timeline

• Start date: 2013-12-25
• Primary completion: 2014-11-30
• Completion: 2014-12-30
• First posted: 2024-10-21
• Last updated: 2024-10-21