NCT06650306

The Impact of Soft Contact Lenses on the Corneal Neuromediators and Optical Quality in High Myopia Prior to SMILE

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 80 (estimated)
• Sponsor: yuhao shao · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

To investigate the influence of Neuromediators expression in corneal stromal lenticules and corneal injury repair after small incision extraction

Detailed description

This study included 160 eyes from high myopia patients who underwent Small Incision Lenticule Extraction. Patients were devided into three groups based on duration of wearing SCLs: \> 10 years group, ≤ 10 years group, and NW group (not SCLs). Corneal higher-order aberrations and densitometry were evaluated using a Pentacam system. Neuromediator levels in corneal stromal lenticules were analyzed using ELISA and immunofluorescence

Conditions

• Contact Lens Complication

Interventions

Type	Name	Description
OTHER	This study does not involve any interventions	This study does not involve any interventions

Timeline

• Start date: 2024-10-18
• Primary completion: 2026-06-30
• Completion: 2026-06-30
• First posted: 2024-10-21
• Last updated: 2024-10-21

Locations

1 site across 1 country: China