NCT06649825

Efficacy of Vitamin B1 in Familial Adenomatous Polyposis Patients.

Evaluation of the Efficacy of Vitamin B1 in Patients with Familial Adenomatous Polyposis: an Exploratory Study

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: Shanghai Zhongshan Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study aimed to investigate the efficacy of vitamin B1 in patients with familial adenomatous polyposis, and to determine the inhibitory effect of vitamin B1 on the size and number of colorectal adenomas by administering oral vitamin B1 therapy for 1 year and colonoscopy follow-up every 3 months

Detailed description

We will mark a region with a diameter of no more than 5 cm, containing at least 3 polyps, each with a diameter of 5-15 mm. Continuous video recording will be conducted throughout the colonoscopy procedure to provide baseline reference images of the colorectal polyps. Patients with familial adenomatous polyposis were given 100mg bid dose of vitamin B1 orally for one year, and colonoscopies were followed every 3 months to observe changes in the size and number of polyps in the designated area.

Conditions

• Familial Adenomatous Polyposis (FAP)

Interventions

Type	Name	Description
DRUG	Vitamin B1	Vitamin B1 tablets, 100mg bid, taken orally for one year

Timeline

• Start date: 2024-01-08
• Primary completion: 2025-04-01
• Completion: 2025-12-01
• First posted: 2024-10-21
• Last updated: 2024-10-21

Locations

1 site across 1 country: China