NCT06648577

3D Ultrasound Myocardial Mechanical Wave Measurements

3D Ultrasound Myocardial Mechanical Wave Measurements in Primary Mitral Regurgitation

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Assistance Publique - Hôpitaux de Paris · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Primary mitral regurgitation (MR) is a frequent disease that can ultimately lead to heart failure. Primary MR represents the second most prevalent cause of cardiac valve surgery in high income countries. Progressive myocardial fibrosis due to chronic volume overload is recognized as a pathophysiological substrate of altered LV function in primary MR. As fibrosis leads to increased myocardial stiffness, ultrasound mechanical wave propagation measurements within the myocardium could provide important clinical information. Natural mechanical wave velocity (MWV) imaging, using High-frame-rate (HFR) echocardiography has emerged as a promising tool to evaluate myocardial stiffness. The objective is study is to evaluate the correlation between the LV myocardial stiffness (as assessed by 3D ultrasound myocardial MWV mapping) and myocardial interstitial fibrosis as measured using CMR (myocardial extracellular volume measure)

Detailed description

After being informed about the study. All patients giving written informed consent will undergo in a routine practice: 1. echocardiography (2D/3D), 2. CMR imaging, 3. electrocardiogram 24 hours monitoring, 4. blood sampling including brain natriuretic peptide measurement, 5. symptom-limited combined exercise echocardiography and oxygen uptake measurements

Conditions

• Chronic Primary Mitral Regurgitation

Interventions

Type	Name	Description
PROCEDURE	Ultrasound imaging	The participants are scanned with an ultrasound scanner

Timeline

• Start date: 2024-10-09
• Primary completion: 2026-11-15
• Completion: 2027-11-14
• First posted: 2024-10-18
• Last updated: 2025-11-18

Locations

2 sites across 1 country: France