NCT06647056

Evaluation of the Effect of a Single Dose of Psilocybin on Neural Correlates of Cognitive Control in Patients With Psychogenic Nonepileptic Seizures

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 4 (actual)
• Sponsor: Centre Hospitalier Universitaire de Nīmes · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Psychogenic non-epileptic seizures (PNES) are functional paroxysmal motor disorders that may be clinically suggestive of epilepsy but are not associated with the electroencephysiological and electroencephalographic changes of epilepsy. Thus, hyper-connectivity of the regions of the default mode network (DMN) linked to executive control could be involved in the impairment of cognitive control capacities in patients suffering from PNES. Also, the HYCORE study (NCT02329626), showed that dysregulation of frontal regions involved in attentional and emotional regulation is correlated with motor symptoms in patients with functional neurological disorders. The researchers of this study hypothesized that psilocybin would improve cognitive control in patients with PNES.

Conditions

• Psychogenic Nonepileptic Seizures
• Psilocybin

Interventions

Type	Name	Description
DRUG	Psilocybin	Administration of psilocybin 25 mg
OTHER	MRI	Two standard MRI + fMRI scans before (D-3) and after (D5) treatment

Timeline

• Start date: 2024-12-19
• Primary completion: 2025-01-03
• Completion: 2025-05-22
• First posted: 2024-10-17
• Last updated: 2025-08-21

Locations

1 site across 1 country: France