NCT06645756

Comparative Analysis of Postprandial Effects in Healthy and Obese Individuals

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 38 (actual)
• Sponsor: University of Hohenheim · Academic / Other
• Sex: All
• Age: 25 Years
• Healthy volunteers: Accepted

Summary

After eating, blood composition changes, including increased triglycerides and glucose, which can trigger postprandial inflammation. Particularly with high-fat foods, pro-inflammatory lipopolysaccharide (LPS) increases. This activates leukocytes to release pro-inflammatory cytokines. In industrialized countries where "snacking" is common, many people spend the day in a postprandial state. Obese individuals tend to have chronic inflammation and show increased susceptibility to infections such as SARS-CoV-2. The main objective of the study is to investigate the response of leukocytes and the serum metabolome after food intake in individuals with obesity compared to healthy individuals, focusing on LPS as a key stimulus of innate immunity.

Conditions

• Obesity
• Normal Weigth

Interventions

Type	Name	Description
OTHER	Test meal	Test meal consisting of fries, chicken nuggets and eggs

Timeline

• Start date: 2023-12-13
• Primary completion: 2024-11-06
• Completion: 2024-11-06
• First posted: 2024-10-17
• Last updated: 2025-08-06

Locations

1 site across 1 country: Germany