NCT06643403

Age-related Changes in Retinal Oxygen Extraction in Healthy Subjects

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Medical University of Vienna · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

It has been found that several systemic and ocular diseases are associated with impaired retinal oxygen extraction. In the present study, retinal oxygen extraction will be measured in different age groups in order to identify age related changes in otherwise healthy subjects. In addition, the study will explore short-term changes in retinal metabolism induced by breathing pure oxygen. Measurements will be performed with dynamic vessel analyzer and laser speckle flowgraphy to evaluate retinal blood flow and retinal oxygen saturation, in order to calculate retinal oxygen extraction.

Conditions

• Healthy Participants
• Retinal Oxygen Extraction

Interventions

Type	Name	Description
DRUG	Oxygen 100% Gas for Inhalation	SAUERSTOFF medizinisch, Messer GmbH, Industriestrasse 5, 2352 Gumpoldskirchen, Austria Dose: min. 95.5%, breathing for max. 45 minutes

Timeline

• Start date: 2024-09-30
• Primary completion: 2025-12-31
• Completion: 2026-01-31
• First posted: 2024-10-16
• Last updated: 2025-11-21

Locations

1 site across 1 country: Austria