NCT06641869

Study of PCC1 for Skin Rejuvenation

A 12-week , Randomized, Open-label Study of PCC1 in Healthy Volunteers for Skin Rejuvenation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 74 (actual)
• Sponsor: Express Rx, Inc · Industry
• Sex: Female
• Age: 45 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This clinical trial will assess the efficacy of PCC1 for skin rejuvenation. The primary objective is to determine whether these interventions enhance skin barrier function, reduce wrinkles, and improve skin texture and radiance over a 12-week period. The study will involve healthy participants applying the treatments and undergoing assessments at baseline, 6 weeks, and 12 weeks. Secondary objectives include evaluating the safety and tolerability of PCC1, with any adverse effects closely monitored during the trial.

Detailed description

As skin ages, intrinsic and extrinsic factors contribute to cellular senescence, disrupting the skin's structure and function. Senescent cells accumulate in the skin, leading to the secretion of senescence-associated secretory phenotype (SASP) factors, which promote inflammation and degrade extracellular matrix proteins like collagen. These changes result in wrinkles, loss of elasticity, and reduced skin barrier function. The study explores anti-senescence strategies using senolytic agents that selectively eliminate senescent cells, aiming to rejuvenate the skin. Compounds like PCC1 and Cellumiva have shown promise in targeting senescent cells by inducing apoptosis and reducing SASP expression, offering a novel approach to skin aging therapy. This clinical trial is designed to evaluate the efficacy and safety of PCC1 in skin rejuvenation over 12 weeks. Healthy female participants aged 45-65 will be randomly assigned to receive PCC1 or a placebo. The study will measure skin barrier function, wrinkle reduction, and texture/radiance improvements using imaging technologies and participant feedback. Safety will also be monitored through adverse event reporting.

Conditions

• Skin Rejuvenation

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	procyanidin C1	Proprietarily extracted procyanidin C1
DIETARY_SUPPLEMENT	Placebo	Placebo
DIETARY_SUPPLEMENT	PCC1 complex	5 mg of procyanidin C1. Frequency: Administered once daily. Duration: 12 weeks.

Timeline

• Start date: 2022-10-10
• Primary completion: 2024-02-23
• Completion: 2024-08-10
• First posted: 2024-10-15
• Last updated: 2025-08-11

Locations

1 site across 1 country: Switzerland