NCT06641297

White Matter Plasticity in Schizophrenia

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (estimated)
• Sponsor: University of Maryland, Baltimore · Academic / Other
• Sex: All
• Age: 15 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

Schizophrenia spectrum disorders are associated with impairment in the microstructure of white matter, the key brain tissue responsible for fast communication between different brain regions necessary for any complex task. This white matter impairment is linked to problems with cognition in schizophrenia, especially slower processing speed. This project aims to study the potential for correcting white matter deficits in schizophrenia by examining mechanisms underlying white matter structure changes in response to training on playing a mock musical instrument.

Conditions

• Schizophrenia Disorders

Interventions

Type	Name	Description
BEHAVIORAL	Music video game	The video game \'Guitar Hero\' will be used as the platform for training for participants to acquire a new \'skill\'

Timeline

• Start date: 2025-01-02
• Primary completion: 2026-12-31
• Completion: 2026-12-31
• First posted: 2024-10-15
• Last updated: 2026-02-20

Locations

2 sites across 1 country: United States