NCT06637813

Establishment of a Database of HIV Subjects Initiating or Simplifying Dual Therapy With Dolutegravir/Lamivudine

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 1,220 (estimated)
• Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The introduction of combination antiretroviral therapy (cART) has completely revolutionized the management of HIV-positive patients, drastically reducing HIV-associated mortality and morbidity. In fact, the course of HIV infection has transformed into a chronic disease. The availability of different classes of antiretroviral drugs, such as nucleoside and non-nucleoside reverse transcriptase inhibitors (NRTIs, NNRTIs), protease inhibitors (PIs), integrase inhibitors (INSTIs) and viral entry inhibitors (IEs) that act in different phases of the HIV life cycle, together with careful patient management, has allowed us to obtain long-lasting therapeutic efficacy in the vast majority of Italian patients, making this infection a chronic disease.

Conditions

• HIV -1 Infection

Interventions

Type	Name	Description
OTHER	Blood sampling for evaluation of biomarkers	Non-routine diagnostic test evaluations

Timeline

• Start date: 2024-10-30
• Primary completion: 2025-10-30
• Completion: 2034-10-30
• First posted: 2024-10-15
• Last updated: 2024-10-15