NCT06637384

Effect of Hyaluronic Acid and Single Dose Corticosteroid Injection to Improve Wound Healing in Controlled Diabetic Patients Post Tooth Extraction.

Effects of Hyaluronic Acid and Corticosteroid in Post Extraction Wound Healing of Diabetic Patients

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 128 (actual)
• Sponsor: Rimsha Rasheed · Academic / Other
• Sex: All
• Age: 25 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to learn if hyaluronic acid and corticosteroid improves wound healing in diabetic patients after oral extraction.

Detailed description

After sample size estimation via Open Epi of 128, randomized clinical trial was performed on the patients from Oral and Maxillofacial Surgery Department in Madinah Teaching Hospital, Faisalabad. Patients were divided into three groups. Group 1 was subjected as control group, Group 2 was treated post extraction with 0.2 % Hyaluronic acid (Gengigel Gingival Gel 20ml, Ricerfarma, Milan, Italy) and Group 3 was treated with single dose Hy-Cortisone Injection 250 mg (Generic name: Hydrocortisone Sodium Succinate, Cirin Pharmaceuticals Pakistan) intramuscularly after extraction. Wound healing was assessed through Landry Healing Index. One-way ANOVA test was applied for comparative analysis and Post Hoc Tuckey's test was applied for pairwise comparisons between the groups

Conditions

• Diabetes Mellitus
• Wound Healing Delayed

Interventions

Type	Name	Description
DRUG	Hyaluronic Acid (HA)	Gengigel Gingival Gel 20ml, Ricerfarma, Milan, Italy
DRUG	Corticosteroid Injection	Hydrocortisone Sodium Succinate, Cirin Pharmaceuticals, Pakistan

Timeline

• Start date: 2024-03-01
• Primary completion: 2024-04-30
• Completion: 2024-07-31
• First posted: 2024-10-15
• Last updated: 2024-10-15

Locations

1 site across 1 country: Pakistan

Regulatory

• FDA-regulated drug study