Trials / Enrolling By Invitation
Enrolling By InvitationNCT06633406
Intelligence and Neurodevelopmental Disorders After Prenatal Exposure to General Anaesthesia
Intelligence and Neurodevelopmental Disorders After Prenatal Exposure to General Anaesthesia for Maternal Abdominal Surgery: A Propensity Score Weighted Multicentre Clinical Bidirectional Cohort Study.
- Status
- Enrolling By Invitation
- Phase
- —
- Study type
- Observational
- Enrollment
- 192 (estimated)
- Sponsor
- Universitaire Ziekenhuizen KU Leuven · Academic / Other
- Sex
- All
- Age
- 2 Years – 27 Years
- Healthy volunteers
- Accepted
Summary
Every year in the European Union, thousands of babies are exposed to anaesthesia before they are born because their mothers need surgery during pregnancy. While these surgeries are necessary, there is a concern that the anaesthesia might affect the baby's brain development. However, there isn't enough research to know for sure how this exposure might impact the child's intelligence or behavior later in life. The goal of this cohort study is to compare the intelligence and neurodevelopmental outcome of children prenatally exposed to general anaesthesia for maternal abdominal surgery with those of unexposed children and with those of children prenatally exposed to maternal inflammation.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Age-appropriate Wechsler Intelligence Test | 2.5-6 years: Wechsler Preschool and Primary Scale of Intelligence for children (WPPSI IV) 7-16 years: Wechsler Intelligence Scale for Children (WISC V) \>17 years: Wechsler Adult Intelligence Scale (WAIS IV) |
| OTHER | Disruptive Behavior Disorders Rating Scale | Dutch version of the Disruptive Behavior Disorders Rating Scale |
| OTHER | Social Responsiveness Scale | 3-18 years: social responsiveness scale 2 (SRS-2) \>19 years: Social Responsiveness Scale - Adult version (SRS-A) |
Timeline
- Start date
- 2024-10-14
- Primary completion
- 2027-10-01
- Completion
- 2027-12-01
- First posted
- 2024-10-09
- Last updated
- 2026-01-09
Locations
3 sites across 1 country: Belgium
Source: ClinicalTrials.gov record NCT06633406. Inclusion in this directory is not an endorsement.