NCT06632067

Sugammadex and Time to Extubation in Ophthalmic Surgery

Comparison of Sugammadex and Neostigmine for Time to Extubation in Adult Patients Undergoing Routine Ophthalmic Surgery Under General Anesthesia

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 262 (actual)
• Sponsor: China Medical University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study is to invastigate if patients treated with sugammadex compared to neostigmine/atropine would be extubate faster upon emergence of anesthesia.

Detailed description

This is a retrospective case-control study including patients aged 18 years or older who underwent ophthalmic surgeries under general anesthesia with tracheal intubation between 2020 and 2022. Patients who received rocuronium as the sole neuromuscular blocking agent and were maintained with sevoflurane or desflurane and intravenous fentanyl were included. Based on the choice of reversal agent for neuromuscular blockade, patients were divided into two groups: the sugammadex group or the neostigmine group. Patients who underwent emergency surgery or combined surgeries with other specialties were excluded. Patient characteristics, including age, gender, ASA classification, weight, and height, were collected. Anesthesia-related medications were recorded. The time points of anesthesia induction, start and end of surgery, reversal agent administration, and tracheal extubation were documented.

Conditions

• General Anesthesia Using Endotracheal Intubation
• Ophthalmologic Surgical Procedure
• Sugammadex
• Neostigmine
• Extubation Readiness

Interventions

Type	Name	Description
DRUG	sugammadex	sugammadex used for neuromuscular reversal
DRUG	Neostigmine + Atropine	Neostigmine and Atropine used for neuromuscular reversal

Timeline

• Start date: 2023-08-01
• Primary completion: 2023-08-31
• Completion: 2023-08-31
• First posted: 2024-10-08
• Last updated: 2024-10-08

Locations

1 site across 1 country: Taiwan