NCT06631560

Hepatitis E Virus Infection in Oncological Patients

Hepatitis E Virus Infection in Oncological Patients - a Prospective Study in Rural Eastern Germany

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 197 (actual)
• Sponsor: Medizinische Hochschule Brandenburg Theodor Fontane · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to investigate the prevalence of hepatitis E infection in oncological patients in a rural region of Germany. Consequently, we conducted prospective testing of blood samples from patients with haematological malignancies for evidence of HEV infection using two distinct anti-HEV IgG and IgM enzyme-linked immunosorbent assays (ELISAs). Serum was taken from each patient before treatment initiation and during treatment follow-up. Primary endpoint was determination of HEV seroprevalence. A healthy cohort was established alongside a cohort of patients who had been hospitalised due to a diagnosis of SARS-CoV-2 infection. In addition, oncological participants completed a questionnaire consisting of eight questions focusing on quantitative aspects, to identify risk factors for HEV infection.

Conditions

• Hepatitis E Infection
• Hepatitis; Epidemic
• Oncologic Disorders

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	ELISA testing	Diagnostic testing was performed by testing all serum samples using the HEV ELISA Wantai and Euroimmun kit.

Timeline

• Start date: 2020-09-01
• Primary completion: 2021-10-29
• Completion: 2024-10-01
• First posted: 2024-10-08
• Last updated: 2024-10-08

Locations

1 site across 1 country: Germany