NCT06629077

Brain Blood Vessel Responses to Changes in Blood Flow

Cerebrovascular Responses to Acute Hypoperfusion

• Status: Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 36 (estimated)
• Sponsor: University of Wisconsin, Madison · Academic / Other
• Sex: All
• Age: 55 Years – 69 Years
• Healthy volunteers: Accepted

Summary

Brain blood flow will be measured during a simulated postural change test and while breathing increased levels of carbon dioxide using magnetic resonance imaging.

Detailed description

Global cerebral blood flow (CBF) decreases with advancing age; however, some adults have accelerated declines in CBF, placing them at a greater risk of cognitive impairment. However, there is a lack of human studies that investigate the cause or consequence of altered blood flow regulation in the brain. This study will systematically address this gap in knowledge by examining cerebrovascular control in adults during acute physiological challenges (simulated postural change test and breathing increased carbon dioxide) that stimulate a change in CBF.

Conditions

• Magnetic Resonance Imaging
• Cerebrovascular Circulation

Interventions

Type	Name	Description
DEVICE	MRI	Participants will undergo an MRI scan while performing breathing and a simulated postural change task.
DRUG	Prazosin	A dose of prazosin will be administered based on body weight.
DRUG	Placebo	Oral placebo

Timeline

• Start date: 2026-02-26
• Primary completion: 2027-01-01
• Completion: 2027-01-01
• First posted: 2024-10-08
• Last updated: 2026-03-02

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study