NCT06627348

Hilotherapy for Prevention of Chemotherapy-induced Peripheral Polyneuropathy

Hilotherapy for Prevention of Chemotherapy-induced Peripheral Polyneuropathy - a Unicentric, Prospective-controlled, Randomized Clinical Trial for Comparison of Local Hilotherapy Vs. No Therapy to Prevent Peripheral Polyneuropathy During Taxan-based Chemotherapy Regimen

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: University of Ulm · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Prospective study of hilotherapy of hands and feet as prevention of chemotherapy-induced peripheral polyneuropathy induced by Taxan-based chemotherapy regimen that are used in the therapy of breast cancer and genital malignoma of the women.

Detailed description

In this trial, patients receiving Taxan-based chemotherapy regimen e.g. paclitaxel, nab-paclitaxel or docetaxel in gynecological malignancies such as ovarian cnacer, breast cancer, endometrial cancer or cervical cancer will either receive cooling of hands and feet during the application of above-mentioned substances or not. The cooling will be provided by a machine called Hilotherm ChemoCare unit and will be administered constantly at a temperature of 15-17°C. Randomization will be 50:50. if a patient is randomized in the non-interventional arm, no cooling is allowed during the application of the chemotherapy. To assess the occurance and the extent of peripheral neuropathy, a neurological examination will take place before the start of chemotherapy, in the middle of the planned cycles of chemotherapy and after the completion of the regimen. Quality of life and the subjective impacts of peripheral neuropathy will be evaluated via questionnaires.

Conditions

• Equipment and Supplies

Interventions

Type	Name	Description
DEVICE	Hilotherm ChemoCare	Hilotherapy

Timeline

• Start date: 2024-04-17
• Primary completion: 2027-03-31
• Completion: 2027-03-31
• First posted: 2024-10-04
• Last updated: 2024-10-04

Locations

1 site across 1 country: Germany