Trials / Recruiting
RecruitingNCT06626412
Longitudinal SV2A and MRI in Premanifest HD
Longitudinal Imaging of Striatal Synaptic Density and Volume in People With Premanifest Huntington's Disease.
- Status
- Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 35 (estimated)
- Sponsor
- Universitaire Ziekenhuizen KU Leuven · Academic / Other
- Sex
- All
- Age
- 20 Years – 75 Years
- Healthy volunteers
- Accepted
Summary
AIM: to compare the sensitivity of SV2A PET and volumetric MRI to detect longitudinal striatal changes in premanifest HD. DESIGN: The investigators will include late premanifest HD mutations carriers and matched healthy controls. All subjects will undergo a clinical examination, with comprehensive assessment of motor and non-motor symptoms, and imaging evaluation consisting of 18F-SynVesT-1 PET and volumetric MRI at baseline and after 2 years.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Diagnostic Test: 18F-SynVesT-1 PET | Positron Emission Tomography (PET) of synaptic vesicle protein 2A (SV2A) using the radioligand 18F-SynVesT-1. |
| DIAGNOSTIC_TEST | Volumetric MRI | Magnetic resonance imaging of brain volume. |
Timeline
- Start date
- 2024-12-04
- Primary completion
- 2028-12-31
- Completion
- 2028-12-31
- First posted
- 2024-10-03
- Last updated
- 2024-12-13
Locations
1 site across 1 country: Belgium
Source: ClinicalTrials.gov record NCT06626412. Inclusion in this directory is not an endorsement.