NCT06625827

A Study of the Effect of Nemtabrutinib (MK-1026) on the Plasma Levels of Digoxin in Healthy Participants (MK-1026-012)

A Study to Evaluate the Effect of Nemtabrutinib on the Pharmacokinetics of Digoxin in Healthy Participants

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Merck Sharp & Dohme LLC · Industry
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The goal of the study is to learn what happens to levels of digoxin in a healthy person's body over time. Researchers will compare what happens to digoxin in the body when it is given with and without another medicine called nemtabrutinib. Researchers are testing if digoxin levels in the body are different when digoxin is given with or without nemtabrutinib.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Digoxin	Oral administration
DRUG	Nemtabrutinib	Oral administration

Timeline

• Start date: 2023-11-07
• Primary completion: 2024-01-22
• Completion: 2024-01-22
• First posted: 2024-10-03
• Last updated: 2024-10-03

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study