NCT06625762

Nantes Bariatric Surgery Cohort

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 300 (estimated)
• Sponsor: Nantes University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

While current research suggests that inflammation of adipose tissue in obesity is linked to accelerated aging, it has yet to be determined in humans how this could enhance preventative and personalized medicine for obese individuals. The NBC study aims to investigate : 1. Whether bariatric surgery is associated with changes in biological age 2. If bariatric surgery alters adipocyte dysfunction, the microbiota and biological rhythms 3. Whether changes in adipocyte dysfunction, microbiota and biological rhythms are linked to changes in biological age. To achieve this, establishing a biocollection before, during and after bariatric surgery will be crucial in addressing these questions

Detailed description

The study of the Nantes Bariatric Surgery Cohort (NBC) aims to evaluate the impact of bariatric surgery on biological age, adipocyte dysfunction, microbiota, and biological rhythms in individuals with obesity. This observational study will include 300 participants over 3.5 years. It involves pre-operative, peri-operative, and post-operative visits to collect clinical, biological, and lifestyle data. Key assessments include anthropometrics, blood tests, questionnaires, and biocollections

Conditions

• Obesity

Interventions

Type	Name	Description
OTHER	Nantes bariatric surgery cohort	The participants will be individuals living with obesity undergoing bariatric surgery

Timeline

• Start date: 2026-03-23
• Primary completion: 2028-03-23
• Completion: 2029-09-23
• First posted: 2024-10-03
• Last updated: 2026-04-03

Locations

1 site across 1 country: France