NCT06622525

Use of Sodium Bicarbonate as Prophylaxis for Kidney Damage in Patients With Heatstroke

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 1 (estimated)
• Sponsor: Hospital General de Mexicali · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study protocol aims to prevent the need for renal replacement therapy in patients with rhabdomyolysis secondary to heatstroke. It is based on previous studies showing that bicarbonate infusion reduces renal failure in similar contexts. The intervention will be conducted at the General Hospital of Mexicali during the summer, targeting the prevention of renal failure and reducing the necessity for renal replacement therapy.

Detailed description

The present study protocol explores the possibility of preventing the need for renal replacement therapy in patients who develop rhabdomyolysis secondary to heatstroke. This is based on previous studies that have used bicarbonate infusion in the context of rhabdomyolysis secondary to compartment syndrome, finding a lower incidence of renal failure. Due to the aforementioned, we propose to carry out a similar intervention at the General Hospital of Mexicali, where there is a significant incidence of heatstroke during the summer months. The aim is to determine whether this intervention is useful in preventing the development of renal failure and the requirement for renal replacement therapy.

Conditions

• Heat Stroke
• Acute Kidney Injury
• Acute Kidney Injury Due to Hypovolaemia

Interventions

Type	Name	Description
DRUG	Sodium bicarbonate	This group will receive 100 mEq of sodium bicarbonate diluted in one liter of saline solution, administered at a rate of 100 ml/h, with the goal of maintaining a urinary pH greater than 6.5.
OTHER	No intervention	The usual management for heat stroke will be given to this group

Timeline

• Start date: 2024-05-01
• Primary completion: 2025-10-01
• Completion: 2025-10-01
• First posted: 2024-10-02
• Last updated: 2024-10-02

Locations

1 site across 1 country: Mexico