Trials / Recruiting
RecruitingNCT06620185
GEneRating Mucosal Immunity After INfluenzA Infection and Vaccination in Lung and Lymphoid TissuE
A Two-arm, Non-randomised, Open-label Experimental Medicine Study to Compare Immune Responses Between Healthy Volunteers Aged 18-40years Receiving Either an Intranasal Live-attenuated Influenza Vaccine or Viral Challenge With GMP Influenza A/Belgium/4217/2015 (H3N2)
- Status
- Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 36 (estimated)
- Sponsor
- Imperial College London · Academic / Other
- Sex
- All
- Age
- 18 Years – 40 Years
- Healthy volunteers
- Accepted
Summary
This experimental medicine study aims to compare immune responses in healthy adult volunteers aged 18-40 years against influenza vaccination and infection in the upper and lower respiratory tract, following administration of a live-attenuated influenza vaccine delivered by nasal spray versus influenza A (H3N2) viral challenge.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BIOLOGICAL | FLUENZ | LAIV (Intranasal Influenza Vaccine) |
| BIOLOGICAL | Influenza challenge virus | Influenza challenge virus (H3N2 strain) |
Timeline
- Start date
- 2025-04-16
- Primary completion
- 2026-01-06
- Completion
- 2026-01-06
- First posted
- 2024-10-01
- Last updated
- 2025-05-02
Locations
1 site across 1 country: United Kingdom
Source: ClinicalTrials.gov record NCT06620185. Inclusion in this directory is not an endorsement.