NCT06619093

Relationship Between Biological Phenotype, Clinical Severity of Sickle Cell Disease, and Blood Coagulation

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: All
• Age: 8 Years
• Healthy volunteers: Not accepted

Summary

Sickle cell disease is characterized by chronic hemolytic anemia and blood rheological alterations. In addition, blood coagulation abnormalities have been reported in patients with sickle cell disease and hemolysis-derived products could be involved. The investigators hypothesized that patients with sickle cell disease and severe hemolysis (Lactate Dehydrogenase level \> 484 IU/L) could have an increased risk of hypercoagulable state and subsequent thromboembolic complications.

Conditions

• Sickle Cell Disease (SCD)

Interventions

Type	Name	Description
OTHER	blood sampling	3 additional citrate tubes (2.7mL)

Timeline

• Start date: 2025-02-01
• Primary completion: 2028-02-01
• Completion: 2028-02-01
• First posted: 2024-10-01
• Last updated: 2025-01-15

Locations

2 sites across 1 country: France