NCT06617949

Evaluating Pain Control Strategies in Postpartum Patients on Opioid Use Disorder Medications.

Evaluating Pain Control Strategies in Postpartum Patients on Opioid Use Disorder Medications: Efficacy and Safety Outcomes.

• Status: Recruiting
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Medical College of Wisconsin · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate the efficacy of three different modalities of post-operative pain control in parturient with opioid use disorders. The investigators aim to determine whether the different approach utilized show better outcomes with pain management and if there are any association with reduction of symptoms of anxiety, depression, and overall well-being.

Conditions

• Substance Use Disorder (SUD)

Interventions

Type	Name	Description
DRUG	Regional Anesthesia	Transverse abdominal Plane(TAP) Block with long acting Exparel placed by a regional anesthesiologist.
DRUG	Hydromorphone Patient Controlled Analgelsic	This group will be administered epidural PCA as a modality for pain control post cesarian section
PROCEDURE	Epidural local anesthetic infusion	Epidural group will receive pain control via a local anesthetic intermediate bolus infusion

Timeline

• Start date: 2025-01-16
• Primary completion: 2027-12-01
• Completion: 2028-12-01
• First posted: 2024-10-01
• Last updated: 2025-10-23

Locations

2 sites across 1 country: United States

Regulatory

• FDA-regulated drug study