NCT06614881

Dexmedetomidine Dosage for Postoperative Delirium and Cognitive Function in Elderly TKA Patients

Optimal Effective Dose of Dexmedetomidine on Postoperative Delirium and Cognitive Function of Elderly Patients Planned For TKA Surgery

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 132 (actual)
• Sponsor: Tanta University · Academic / Other
• Sex: All
• Age: 35 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study aims to evaluate the efficacy of dexmedetomidine in reducing the incidence of postoperative delirium and cognitive dysfunction in elderly patients undergoing total knee arthroplasty (TKA). The study will compare the outcomes of patients receiving dexmedetomidine to those receiving a standard anesthetic or sedative, focusing on factors such as patient characteristics, surgical duration, and postoperative care. The research will explore the potential neuroprotective effects of dexmedetomidine and its ability to mitigate the risks associated with anesthesia and surgery in vulnerable elderly populations.

Conditions

• Post Operative Delirium

Interventions

Type	Name	Description
DRUG	Dexmedetomidine Injection [Precedex]	Dexmedetomidine (Precedex, 100 µg/ml) was provided as an intravenous (IV) loading dose of 1 µg/kg over 10-min
DRUG	Dexmedetomidine in 0.9 % NaCl 1,000 Mcg/250 mL (4 Mcg/mL) INTRAVEN INFUSION BOTTLE (ML)	Dexmedetomidine infusions were prepared to provide 0.5 µg/kg/h
DRUG	Dexmedetomidine in 0.9 % NaCl 1,000 Mcg/250 mL (4 Mcg/mL) INTRAVEN INFUSION BOTTLE (ML)	Dexmedetomidine infusions were prepared to provide 0.7 µg/kg/h
DRUG	Dexmedetomidine in 0.9 % NaCl 1,000 Mcg/250 mL (4 Mcg/mL) INTRAVEN INFUSION BOTTLE (ML)	Dexmedetomidine infusions were prepared to provide 1.1 µg/kg/h
DRUG	Normal saline	loading dose of saline was injected 10-min before induction of anesthesia.

Timeline

• Start date: 2024-07-01
• Primary completion: 2024-10-15
• Completion: 2024-11-01
• First posted: 2024-09-26
• Last updated: 2024-11-26

Locations

1 site across 1 country: Egypt