NCT06613893

Effect of Inhalational Anesthesia Versus Total Intravenous Anesthesia on Blood Glucose in Type 2 Diabetes Patients

Effect of Inhalational Anesthesia Versus Total Intravenous Anesthesia on Blood Glucose Level in Type 2 Diabetes Mellitus Patients Undergoing Thoracic Surgery : a Comparative Study

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 84 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 30 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to compare the effect of total intravenous anesthesia (TIVA) and inhalational anesthesia (IHA) as maintenance anesthesia on blood glucose level and complications in type 2 diabetic patients undergoing thoracic surgery . All participants had to understand and give written informed consent , and ethical committee approval (of Faculty of Medicine, Ain Shams University) will be obtained before participants allocation.

Detailed description

* Type of Study: prospective , randomized . * Study Settings: Ain Shams University hospitals, Cairo, Egypt. * Study period: 12 months starting from janurary 2024 . * Study Population: All adult type 2 diabetic patients (30-70 year old) with class II,III based on the American Society of Anesthesiologists (ASA) physical status undergoing elective thoracic surgeries will be randomly assigned into one of the following groups using computer generated codes and opaque sealed envelopes: 1. Group A will receive total inravenous anesthesia (TIVA). 2. Group B will receive inhalational anesthesia (IHA)

Conditions

• Type 2 Diabetes Mellitus (T2DM)
• Thoracic Surgery

Interventions

Type	Name	Description
DRUG	TIVA	Anesthesia will be maintained by total intravenous anesthesia with propofol infusion (4 to 12 mcg/kg/min) and fentanyl infusion (1-2mcg /kg/hour) that will be stopped 30 min before the end of the operation ,The heart rate and blood pressure will be maintained within the range of ±20% of the baseline
DRUG	Inhalational anesthesia	Anesthesia will be maintained with inhaled isoflurane, Iso-MAC from (0.7 to 1.4%)(Hawkley, Preston, and Maani 2018) and fentanyl infusion (1-2mcg /kg/hour) that will be stopped 30 min before the end of the operation ,The heart rate and blood pressure will be maintained within the range of ±20% of the baseline

Timeline

• Start date: 2024-01-01
• Primary completion: 2024-12-31
• Completion: 2025-06-30
• First posted: 2024-09-26
• Last updated: 2025-05-29

Locations

1 site across 1 country: Egypt