NCT06613542

Effects Of Daily Taurine Intake For 6 Months On Biological Age and Body Metabolism Indicators As Well As Physical Fitness In 55-75-year-old Women And Men

Effect Of Daily Taurine Supplementation For 6 Months On Biological Age and Metabolic Biomarkers As Well As Physical Fitness In 55-75-year-old Women And Men: A Randomized Controlled Intervention Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Technical University of Munich · Academic / Other
• Sex: All
• Age: 55 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The goal of this clinical trial is to investigate the effect of taking 4 grams of taurine by older adults on aging processes over a period of 6 months. It will also check for effects of taurine on participant's physical fitness, metabolic and cognitive functions. The main question it aims to answer is: • Does a supplementation with 4 g of taurine daily over a period of 6 months slow down biological aging in humans? Researchers will compare supplementation with taurine to a placebo (a look-alike substance that contains no drug) to reliably determine whether taurine has an effect. Participants will: * Take 4g of taurine or a placebo every day for 6 months * Visit the study site 4 times for checkups and tests: for a screening visit, at the beginning of the intervention, after 8 and 24 weeks

Detailed description

Measurements performed during study visits: * Biological age estimate via proteome analysis * Organ age estimates (proteomics) * DNA methylation * Inflammatory biomarkers (CRP, cytokines) * Metabolic variables: fasting blood glucose, insulin, HOMA-IR, HbA1c, lipids, BMI * Physical fitness (hand grip strength, leg extensor strength, PWC130) * Resting energy expenditure * Cognitive function via questionnaire * Quality of life * Heart rate variability * Physical activity, nutrition

Conditions

• Taurine
• Aging, Biological
• Physical Activity
• Metabolic Health
• Anti-Aging
• Longevity
• Dietary Supplement
• DNA Methylation
• Sport

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	4g of taurine daily	Intervention group (4g of taurine/day): 2g of taurine (4 capsules, 500mg each) in the morning and 2g of taurine (4 capsules, 500mg each) in the evening for 6 months
DIETARY_SUPPLEMENT	Placebo	Controll group (4g of placebo/day): 2g of placebo (4 capsules, 500mg each) in the morning and 2g of placebo (4 capsules, 500mg each) in the evening for 6 months

Timeline

• Start date: 2024-09-25
• Primary completion: 2025-11-13
• Completion: 2025-11-13
• First posted: 2024-09-26
• Last updated: 2025-11-21

Locations

1 site across 1 country: Germany