NCT06612372

Effects of 60-day-6° Head-down Bed Rest on Cartilage and Function of the Knee Joint

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (estimated)
• Sponsor: Peking University Third Hospital · Academic / Other
• Sex: Male
• Age: 25 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Objective: To investigate the effects of long-term simulated unloading in bed on articular cartilage quality based on functional magnetic resonance imaging (FMRI) and Knee joint function.

Detailed description

A total of 26 subjects were recruited for a 60-day period of head-down bed rest (HDBR). The bed rest position is a 6° downward tilt of the head, and all daily activities are performed in this position. We will perform functional MRI scans of the right knee joint using T2 mapping sequences to assess tissue composition and water content before and after HDBR. Functional assessments, including the Y-Balance Test and International Knee Documentation Committee (IKDC) scores, were performed pre-HDBR and post-HDBR.We will divide each participant's knee cartilage into 18 regions and measured T2 values according to the whole organ magnetic resonance imaging score (WORMS) partitioning method.

Conditions

• Cartilage Degeneration
• Weightlessness

Interventions

Type	Name	Description
BEHAVIORAL	60-day-6° head-down bed rest	Throughout the bed rest period, subjects carried out all activities of daily living-eating, voiding, recreation, and testing

Timeline

• Start date: 2023-09-10
• Primary completion: 2024-11-10
• Completion: 2024-11-15
• First posted: 2024-09-25
• Last updated: 2024-09-25

Locations

1 site across 1 country: China