NCT06610383

Evaluation of the Effect of Circadian Rhythm of Adrenal Glucocorticoids After Third Molar Extraction

Effect of Circadian Rhythm of Adrenal Glucocorticoid on Pain, Swelling, and Trismus After Surgical Removal of Mandibular Third Molars

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 20 (actual)
• Sponsor: Afyonkarahisar Health Sciences University · Academic / Other
• Sex: All
• Age: 18 Years – 25 Years
• Healthy volunteers: Accepted

Summary

This study aimed to investigate the effects of wisdom tooth surgery performed at different times of the day on pain, swelling and trismus based on changes in the circadian rhythm in the adrenal glands in patients aged between 18-25 years who applied to the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Afyonkarahisar Health Sciences University with complaints of pain and swelling due to wisdom teeth.

Detailed description

This clinical study was conducted on 20 patients who applied to the Afyonkarahisar Health Sciences University (AFSU) Faculty of Dentistry, Department of Oral and Maxillofacial Surgery between November 2021 and July 2022 for surgical extraction of mandibular impacted third molars in the same impaction class (Mesioangular-Pell and Gregory class II-B) bilaterally. This study was created by including 20 patients who applied to the AFSÜ Faculty of Dentistry, Oral, Dental and Maxillofacial Surgery Clinic due to the presence of impacted teeth and/or complaints caused by their impacted teeth, and who were decided to have symmetrical, bilateral, bone-retained (Mesioangular) third molars in the mandible extracted as a result of clinical examination and radiographic evaluations. Participation in this study was completely up to the participant. If the participant did not want to participate in the study or withdrew, the doctor still applied the most appropriate treatment plan for the participant. During the surgery for your wisdom teeth, we took a saliva sample from the participant before anesthesia, on the 2nd and 7th postoperative days, and measured the amount of steroids secreted from your body through your saliva. The participant\'s pain, swelling, and trismus values were assessed using reference points on your face and pain scales on the day he/she came to the surgery, the 2nd day, and the 7th day. The study has no risks or discomfort. Based on the results of this study, surgeons will be able to evaluate the effects of adrenal steroids at different times of the day and determine when their procedures will be more comfortable. Participants did not incur any financial burden by participating in the study, and no payment was made to the participants. The researchers will use the participants\' personal information to conduct the study and statistical analyses, but the participants\' identities will be kept confidential. Ethics committees or official authorities may review the participants\' information only when necessary. At the end of the study, the study results may be published in the medical literature, but your identity will not be disclosed.

Conditions

• Wisdom Teeth

Interventions

Type	Name	Description
PROCEDURE	Surgical extraction of wisdom teeth in the morning	The patients in this group underwent impacted tooth surgery at 08:30 in the morning.
PROCEDURE	Surgical extraction of wisdom teeth in the afternoon	Impacted tooth surgery was performed on the patients in this group at 15:30.

Timeline

• Start date: 2021-11-11
• Primary completion: 2023-05-01
• Completion: 2023-11-01
• First posted: 2024-09-24
• Last updated: 2024-09-24

Locations

1 site across 1 country: Turkey (Türkiye)