NCT06605703

A Randomized Controlled Trial Comparing the Effectiveness of Different Treatment Options for Weight Management After Discontinuation of Semaglutide and Tirzepatide (GLP1 Transition Trial)

The Comparative Effectiveness of Step-down Treatment Options for Weight Management After Discontinuation of Semaglutide and Tirzepatide: A Randomized Controlled Trial (GLP1 Transition Trial)

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 226 (actual)
• Sponsor: WW International Inc · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study compares the effectiveness of treatment options for weight management after discontinuing semaglutide and tirzepatide. The primary outcome is absolute and percentage weight change at 12-weeks.

Conditions

• Obesity
• Overweight

Interventions

Type	Name	Description
BEHAVIORAL	WW Clinic	Telehealth platform that specializes in medical weight management and integrates the behavioral and lifestyle support from WW.
DRUG	Bupropion-Naltrexone	Bupropion-Naltrexone
DRUG	Bupropion-Naltrexone-Metformin	Bupropion-Naltrexone-Metformin

Timeline

• Start date: 2024-09-18
• Primary completion: 2026-02-05
• Completion: 2026-02-05
• First posted: 2024-09-20
• Last updated: 2026-04-13

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study