NCT06605300

The Effects of Oxytocin and Vasopressin on Delta-beta Cross-frequency Coupling

The Modulatory Effects of Oxytocin and Vasopressin on Delta-beta Cross-frequency Coupling

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: University of Electronic Science and Technology of China · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The main aim of the study is to investigate whether intranasal oxytocin and vasopressin have effects on delta-beta cross-frequency coupling under resting-state and task conditions.

Detailed description

A double-blinded, placebo-controlled, between-subject design is employed in this study. In a randomized order, a total of 120 healthy males and females are instructed to self-administer intranasal spray of oxytocin, vasopressin, or placebo. (1) 15-minute resting-state EEG data are collected 35 minutes after treatment. (2) Participants complete tasks including Stroop, GO/NOGO, and anxiety induction with behavioral (response time, accuracy, or rating) and EEG data being collected. Personality traits of subjects are assessed using validated Chinese version questionnaires including the Beck Depression Inventory (BDI-II), State-Trait Anxiety Inventory (STAI), Autism Spectrum Quotient (ASQ), and Adult ADHD Self-Report Scale (ASRS-v1.1). Participants are asked to complete Positive and Negative Affect Schedule (PANAS) when they just arrive, before resting state and after the tasks. Three blood samples (5 ml) are collected into 6 ml ETDA tubes when participants just arrive, before resting state recording and after all of the tasks.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	Intranasal Oxytocin (IN-OXT)	Subject assigned to receive intranasal administration of oxytocin (24 IU).
DRUG	Intranasal Vasopressin (AVP)	Subjects assigned to receive intranasal administration of vasopressin (20 IU).
DRUG	Intranasal Placebo	Subjects assigned to receive intranasal administration of placebo.

Timeline

• Start date: 2024-10-02
• Primary completion: 2025-07-28
• Completion: 2025-08-12
• First posted: 2024-09-20
• Last updated: 2025-10-03

Locations

2 sites across 1 country: China