NCT06603207

Study of the Causal Link Between Rheumatoid Arthritis and Periodontitis Using Mendelian Randomization

Causal Association Between Rheumatoid Arthritis and Periodontitis: A Mendelian Randomization Study

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 220,000 (estimated)
• Sponsor: Zhibin Xu · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

This study aims to investigate the causal relationship between rheumatoid arthritis and periodontitis using Mendelian randomization. Data will be sourced from genome-wide association studies (GWAS) to explore genetic associations and assess potential risk factors in an East Asian population.

Detailed description

The purpose of this study is to explore the causal association between rheumatoid arthritis (RA) and periodontitis using Mendelian randomization (MR). RA and periodontitis share similar inflammatory pathways and immune responses, but their causal relationship remains unclear. This study will utilize genome-wide association studies (GWAS) data from an East Asian population to identify single nucleotide polymorphisms (SNPs) associated with RA and assess their potential impact on the risk of developing periodontitis. Statistical methods such as inverse-variance weighting, MR-Egger regression, and weighted median analysis will be employed to analyze the data. The findings may provide insights into the shared genetic basis and causal relationships between these two conditions, offering potential targets for preventive strategies.

Conditions

• Rheumatoid Arthritis
• Periodontitis

Timeline

• Start date: 2024-10-01
• Primary completion: 2024-11-01
• Completion: 2024-12-01
• First posted: 2024-09-19
• Last updated: 2024-09-20