NCT06603064

Neuromodulation of Brain and Emotional Responses to Psychological Stress

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 55 (estimated)
• Sponsor: University of Pittsburgh · Academic / Other
• Sex: All
• Age: 30 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Investigators are conducting this study to test if temporarily and non-invasively stimulating the brain will affect the emotional response to stress in healthy participants. Participants will perform a series of tasks while completing an MRI scan. After this, participants will be randomized to undergo transcranial magnetic stimulation (TMS) at two visits, undergoing active stimulation at one visit and undergoing 'sham' stimulation at another visit. Immediately following both stimulation sessions, participants will repeat the tasks during MRI scanning.

Conditions

• Healthy
• Anxiety

Interventions

Type	Name	Description
DEVICE	Active continuous theta burst stimulation	This intervention involves an active form of continuous theta burst stimulation (cTBS) that will be targeted to the dorsal anterior cingulate cortex based on neural navigation software. cTBS will be delivered in one session, lasting a few minutes, before participants complete additional testing.
DEVICE	Sham continuous theta burst stimulation	This intervention involves an sham form of continuous theta burst stimulation (cTBS) that will be targeted to the dorsal anterior cingulate cortex based on neural navigation software. cTBS will be delivered in one session, lasting a few minutes, before participants complete additional testing.

Timeline

• Start date: 2025-04-09
• Primary completion: 2028-07-01
• Completion: 2029-07-01
• First posted: 2024-09-19
• Last updated: 2025-05-04

Locations

1 site across 1 country: United States