NCT06602141

Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance Exercise

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (estimated)
• Sponsor: AdventHealth Translational Research Institute · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of this research study is to study the effects of endurance exercise training on adipose (fat) tissue quality and insulin sensitivity in men and women.

Conditions

• Obesity

Interventions

Type	Name	Description
PROCEDURE	Muscle Biopsy	This procedure is used to sample muscle cells from the leg Vastus Lateralis (thigh) muscle.
PROCEDURE	Adipose Biopsy	This procedure is used to sample fat tissue from the abdomen (belly).
OTHER	Glucose Clamp	In this test, we will measure the effect of insulin by giving you insulin and glucose (sugar) intravenously through an IV line in your arm.
OTHER	Accelerometer	The tri-axial accelerometer measure activity and uses those values to estimate the number of calories burned based on your height, weight, age, and gender. The monitor also evaluates physical effort and the body's response to different activities.
OTHER	Endurance Exercise	Visit the study site 3 times a week to engage in endurance exercise training for approximately 12 weeks. Each session will last approximately 75 minutes, and exercise group can choose to use either a stationary bike or a treadmill to complete the training.
OTHER	Physical activity/ dietary habits	Visit the study site bi-weekly to get weight measurements and speak to the study team about weight maintenance and participant physical activity/dietary habits.
OTHER	Heavy Water Labeling Period	Participants in both control groups will be required to drink heavy water, which is ordinary water that is enriched with deuterium (stable, non-radioactive isotope) and called deuterium-labeled water, for 12 weeks.

Timeline

• Start date: 2024-09-11
• Primary completion: 2029-04-01
• Completion: 2029-04-01
• First posted: 2024-09-19
• Last updated: 2026-03-27

Locations

2 sites across 1 country: United States