NCT06601374

Patient Presented With AKI Related to Pregnancy

Characteristics and Outcomes of Patients With Pregnancy Related Acute Kidney Injury in Assiut University Hospitals: a Single-center Study

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 57 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The primary objective of this study is to identify characteristics of patient with PR AKI treated in Assiut university hospital Secondary outcomes: 1. Assessment of pregnancy related AKI maternal outcome (complete recovery , partial recovery or progress to ESRD) within 3 months duration 2. To identify predictors of unfavorable outcome of patient with pregnancy related AKI

Detailed description

Acute kidney Injury (AKI) is a syndrome which is characterized by an rapid deterioration of the kidney function , manifested by increase in serum creatinine level with or without reduced urine output and linked to high rate of morbidity and mortality .AKI is considered a major public health problem despite much improvmnent in heakth care and especially, most of them (about 85 %) in developing countries with low resources.Pregnancy related AKI ( PR -AKI ) is a major obstetric complication which may cause termination of pregnancy (TOP ), Intensive care unit ( ICU ) admission , need for dialysiy , both maternal and perinatal morbidity and mortality with maternal mortality rang from 9% to 55 % . PR-AKI has a major risk factors include preeclampsia which is the most common cause (15-20%) , hyperemesis gravidarum , acute fatty liver of pregnancy and placental abruption , puerperal sepsis and septic abortion .The maternal outcome of pregnancy related AKI include complete recovery with return of serum creatinine to normal (\> 1.4 mg /dl ) about (40-75% ), partial recovery(4-9% require dialysis about 4 months after delivery) , progress to End stage renal disease (1.5 - 2.5 %) or maternal mortality . The maternal mortality rate (MMR) increases with increasing severity of pregnancy-related complications and can range from 13 to 24% in developing countries due to PR-AKI . Timely identification of patients and management of underlying conditions is considered the cornerstone to improve maternal outcome.

Conditions

• Acute Kidney Injury

Timeline

• Start date: 2024-10-01
• Primary completion: 2025-10-01
• Completion: 2025-12-01
• First posted: 2024-09-19
• Last updated: 2024-09-19