NCT06600646

Investigating the Role of ATP Production by Airway Epithelium in Patients With Refractory and Unexplained Chronic Cough (RCC/UCC).

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: McMaster University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Chronic cough is a common troublesome symptom which has a global prevalence of approximately 10%, but with wide variations across continents. Patients with refractory and unexplained chronic cough (RCC/UCC) often exhibit dysregulated vagal pathways, necessitating a neuronal biomarker for targeted treatment. ATP, involved in the ATP/P2X3 pathway, may serve as a potential biomarker due to its role in the cough reflex. The study aims to discover if ATP production by the airway epithelium is greater in RCC/UCC patients compared with healthy controls, if the epithelium is a source of ATP, whether gene and protein expression related to ATP production differs between these groups and whether ATP release is triggered by mechanical and chemical stimulation. Additionally, the study seeks to determine if biomarker gene expression signatures can differentiate RCC/UCC patients from healthy controls.

Conditions

• Chronic Cough (CC)

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Bronchoscopy	Bronchoscopy will be performed in patients with refractory or unexplained chronic cough and healthy controls.

Timeline

• Start date: 2024-11-22
• Primary completion: 2025-10-01
• Completion: 2025-12-31
• First posted: 2024-09-19
• Last updated: 2025-05-08

Locations

1 site across 1 country: Canada

Regulatory

• FDA-regulated device study