NCT06600048

Spinal Anesthesia by Hyperbaric Prilocaine in Day-Case Perianal Surgery

Spinal Anesthesia by Hyperbaric Prilocaine in Day-Case Perianal Surgery: A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Tanta University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to evaluate the effect of spinal anesthesia by hyperbaric prilocaine in day-case perianal surgery.

Detailed description

Day-case spinal anesthesia with short-acting local anesthetics such as lidocaine and chloroprocaine can provide short times to discharge. However, the association of lidocaine with transient neurologic symptoms (TNS) and chloroprocaine with neurologic injury has limited the use of these agents in spinal anesthesia. Hyperbaric bupivacaine has been used for spinal anesthesia for decades owing to the low incidence of TNS. Prilocaine is also an amide local anesthetic that has an intermediate duration of action. It is available in the hyperbaric form that can be used for spinal anesthesia in day-case surgeries. Hyperbaric prilocaine provides faster spinal block onset and earlier patient recovery in ambulatory surgery compared to plain prilocaine.

Conditions

• Spinal Anesthesia
• Hyperbaric
• Prilocaine
• Day-Case
• Perianal Surgery

Interventions

Type	Name	Description
DRUG	Hyperbaric prilocaine	Patients will receive 1.5 ml (30 mg) 0.5% hyperbaric prilocaine.
DRUG	Hyperbaric bupivacaine	Patients will receive 1.5 ml (7.5 mg) 0.5% hyperbaric bupivacaine.

Timeline

• Start date: 2024-09-17
• Primary completion: 2025-03-01
• Completion: 2025-03-01
• First posted: 2024-09-19
• Last updated: 2025-03-27

Locations

1 site across 1 country: Egypt