NCT06598891

PAS Balance Training for Parkinson Disease (PD)

Effect of Combined PAS Balance Training on Individuals With PD

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Chang Gung University · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

Gait initiation (GI) difficulty is a common problem in individuals with Parkinson's disease (PD), often linked to impaired anticipatory postural adjustments (APA). Currently, there are no targeted rehabilitation programs designed specifically for GI-related APA in PD patients. Research has shown that while motor learning deficits are common in PD, explicit learning is better preserved than implicit learning. Therefore, a GI-related APA training system using an explicit learning model could be particularly effective for this population. During motor learning, long-term potentiation (LTP) increases the excitability of the primary motor cortex. Paired associative stimulation (PAS) has been demonstrated to induce LTP-like changes in the motor cortex, making it a potential priming method to enhance motor learning. However, the priming effect of PAS targeted at leg muscles and the motor cortex on motor learning related to GI-APA has not been previously studied. The objectives of this study are: 1. To investigate the effects of explicit and implicit training on GI-related APA. 2. To evaluate the priming effect of PAS on GI-related APA training and the associated plasticity changes in the motor cortex.

Conditions

• PD - Parkinson's Disease

Interventions

Type	Name	Description
PROCEDURE	Weight shift training and APA feedback	Use COP trajectory to train weight shift on force plate. To give APA visual feedback for subjects after weight shift training.
PROCEDURE	Paired associative stimulation	Use TMS combine ES to stimulate TA nerve and M1 cortical

Timeline

• Start date: 2024-10-09
• Primary completion: 2026-05-01
• Completion: 2026-05-01
• First posted: 2024-09-19
• Last updated: 2024-10-10

Locations

1 site across 1 country: Taiwan