NCT06598514

Chlorhexidine Lavage for Recurrent Urinary Tract Infection

Effect of Chlorhexidine Perineal Lavage Following Defecation in Post-Menopausal Women With Recurrent Urinary Tract Infection

• Status: Active Not Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 136 (estimated)
• Sponsor: Oregon Health and Science University · Academic / Other
• Sex: Female
• Age: 55 Years – 89 Years
• Healthy volunteers: Not accepted

Summary

A two-arm randomized control trial evaluating rates of urinary tract infection in post-menopausal women on vaginal estrogen with recurrent urinary tract infections.

Detailed description

There is a critical need for low-cost, non-antibiotic interventions that are feasible for patients to utilize for risk reduction and prevention of recurrent urinary tract infections (UTIs). The current most effective non-antibiotic prophylaxis for recurrent UTI is vaginal estrogen; however, approximately 50% of women will continue to experience UTIs. The investigators propose a randomized control trial of postmenopausal women on vaginal estrogen with the diagnosis of recurrent UTIs to evaluate a novel post-defecation hygienic strategy utilizing a 2% chlorhexidine perineal lavage. Participants will be randomized to either a 2% chlorhexidine perineal lavage or a water lavage. Study participants will be followed for up to 6-months, and UTIs will be tracked with culture proven samples throughout study participation.

Conditions

• Urinary Tract Infections
• Recurrent Urinary Tract Infection

Interventions

Type	Name	Description
DRUG	Chlorhexidine	Participants will use a 2% chlorhexidine perineal lavage following defecation
DRUG	Sterile Water	Participants will use a sterile water perineal lavage following defecation

Timeline

• Start date: 2024-12-23
• Primary completion: 2026-04-01
• Completion: 2026-06-01
• First posted: 2024-09-19
• Last updated: 2026-01-15

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study