NCT06594315

Assessing Brain Metabolism Using MRS With Deuterated Glucose

Assessing Brain Metabolism Using 1H MRS With Deuterated Glucose

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 80 (estimated)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study will investigate the use of Hydrogen 1 (1H) magnetic resonance spectroscopy (MRS) with deuterated glucose (2H-glucose) to detect dynamic glucose uptake in the brain.

Detailed description

PRIMARY OBJECTIVE: 1. To define the most appropriate imaging parameters of 1H MRS for obtaining deuterium-labeled glucose metabolism (Cohorts 1 and 2). 2. To evaluate treatment induced metabolic changes after the administration of 2H-glucose in participants with glioma (Cohort 3). OUTLINE: Participants with and without glioma will be evaluated to develop a robust strategy for obtaining 2H-glucose metabolism in twenty healthy participants (cohort 1) and thirty participants with glioma (cohort 2), while the remaining thirty glioma participants will be studied at baseline and after completion of non-investigational therapy (cohort 3).

Conditions

• Glioma

Interventions

Type	Name	Description
DRUG	Deuterated Glucose	Given orally
PROCEDURE	Magnetic Resonance Imaging (MRI)	Imaging procedure performed at University of California, San Francisco
PROCEDURE	Blood Sample	Capillary blood from the fingertip
PROCEDURE	MR spectroscopy (MRS)	Imaging procedure performed at University of California, San Francisco

Timeline

• Start date: 2022-07-20
• Primary completion: 2027-07-31
• Completion: 2027-07-31
• First posted: 2024-09-19
• Last updated: 2025-09-18

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study