NCT06593535

Evaluation of Astaxanthin Properties on Anti-fatigue

Short-term Astaxanthin Supplementation Enhances Cycling Performance and Attenuates Exhaustive Exercise-induced Muscle Damage and Oxidative Stress in Young Healthy Adults: A Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: China Medical University Hospital · Academic / Other
• Sex: Male
• Age: 20 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Ten young, healthy, physically active male college students were crossed over for AST or placebo supplements randomized into placebo or AST trials and orally consumed placebo or AST (28 mg/d) supplements for four days. Short-term AST supplementation enhanced endurance performance and effectively reversed cycling challenge-induced muscle damage and lipid peroxidation.

Detailed description

AST is composed of two β-ionone ring systems that are linked by a polyene chain and contain oxygenated keto and hydroxyl moieties, which are responsible for its powerful antioxidant activity. AST has been shown to have numerous health benefits in humans, including improved antioxidant and inflammatory status under different stress conditions. Therefore, this study will explore AST supplement to improve exercise-induced muscle damage and/or physiological anomalies in adults. Ten physically active male adults were randomized into placebo or AST trials and consumed placebo or AST (28 mg/d) supplements orally for 4 days. On day-4, participants performed an exhaustive cycling challenge at 75% V̇O2max, and the time to exhaustion (TTE) was recorded. Blood and gaseous samples were collected before, during, and immediately after cycling to determine changes in muscle damage, inflammation, oxidative stress, and substrate utilization.

Conditions

• Healthy Volunteer

Interventions

Type	Name	Description
OTHER	Placebo (Placebo trial)	The Placebo capsule supplement was taken for 4 days (7 capsules per day)
OTHER	Astaxanthin (AST trial)	The AST capsule supplement was taken for 4 days, with a daily dosage of 28 mg of AST (equivalent to 7 capsules per day, each containing 4 mg of AST).

Timeline

• Start date: 2022-06-25
• Primary completion: 2022-07-17
• Completion: 2022-09-20
• First posted: 2024-09-19
• Last updated: 2024-09-19

Locations

1 site across 1 country: Taiwan