NCT06592690

Effect of Rate-responsive Compared to VDD Pacing in Cardiac Resynchronization Therapy Recipients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (actual)
• Sponsor: Ospedale Centrale Bolzano · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to understand the best programming pacing mode for cardiac resynchronization therapy devices used to treat chronic heart failure.

Detailed description

Cardiac resynchronization therapy (CRT) efficacy trials to date used atrial-synchronous biventricular pacing wherein there is no or minimal atrial pacing. However, bradycardia and chronotropic incompetence are common in this patient population. Despite neutral results on hard clinical outcomes of the atrial support in CRT patients, it is not clear if a rate-responsive pacing may add incremental benefits on exercise capability. The aim of this study is to assess the impact of RR pacing compare to VVD pacing in patients implanted with CRT devices in term of functional capacity, measured by the six-minute walking test (6MWT). This simple test has shown to be an independent predictors of mortality in this cohort of patients.

Conditions

• Heart Failure, Wide QRS Complex

Interventions

Type	Name	Description
OTHER	Atrial pacing support	Use a pacing mode with atrial pacing including a rate-resposive sensor.
OTHER	Atrial tracking pacing mode	A pacing mode which allows sensing of intrinsic sinus rhythm as much as possible to avoid unnecessary atrial pacing is the preferred programming in patients with CRT without atrial pacing indication. VDD pacing mode met these criteria.

Timeline

• Start date: 2017-11-27
• Primary completion: 2021-09-17
• Completion: 2021-09-17
• First posted: 2024-09-19
• Last updated: 2024-09-19

Locations

1 site across 1 country: Italy