NCT06591728

PCA Loading Time Before Knee Prosthetic Joint Infection Revision

The Effects Of Dietary Protocatechuic Acid (PCA) On The Function And Structure Of Participants With Prosthetic Joint Infection (PJI) Before Revision Surgery, As Measured By Standard Biomarkers

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (estimated)
• Sponsor: Dr. Dean Reeves Clinic · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Proof of principle pilot study of the effect of dietary nutritional loading of protocatechunic acid (PCA) on the health and welfare of individuals with prosthetic joint infection (PJI), as measured by standard biomarkers

Detailed description

Our purpose in the pre-surgery serial aspiration study is to determine the optimal PCA loading time duration for those with knee PJI with planned single or two stage revision.Our hypothesis, related to changes in structure and function as a result of PCA administration is that dietary nutritional loading of this nutraceutical PCA via the oral route will benefit the health and welfare of such a subject and alter the function and or structure of the human body having a PJI, as measured by improvemen in a pain biomarker, and one or more laboratory-based biomarkers.

Conditions

• Prosthesis-Related Infections

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Oral PCA	Administration of 1,000 mg BID of oral PCA in individuals with knee prosthetic joint infection prior to revision surgery

Timeline

• Start date: 2025-03-01
• Primary completion: 2025-08-01
• Completion: 2025-12-01
• First posted: 2024-09-19
• Last updated: 2025-02-05