NCT06587828

A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: TScan Therapeutics, Inc. · Industry
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The most clinically meaningful way to discover new targets of T cells in autoimmune diseases is to study the tissues of patients with active autoimmune disease mediated organ inflammation. These tissues contain both cytotoxic and helper T cells that are driving their disease, and these T cells are being guided by TCRs that recognize tissue-specific targets. By collecting tissue when a patient has active inflammation, it is possible to determine which T cells are activated and undergoing clonal expansion in the patient's diseased organ. TScan has developed a genome-wide, high-throughput technology to determine the natural, physiological target of any TCR (Kula, 2019). The goal of this study is to isolate T cells from inflamed tissues and matched blood samples and/or matched normal tissues (for patients with inflammatory bowel diseases). T cell clones that are expanded in diseased tissues relative to blood or normal tissues will be selected and the targets of their TCRs will be defined using TScan's genome-wide, high-throughput target ID technology. The goal of this study is to discover a collection of peptide targets, along with their associated TCRs to be developed as new tolerogenic therapies for patients with autoimmune diseases.

Conditions

• Autoimmune Diseases
• Ulcerative Colitis
• Multiple Sclerosis
• Scleroderma
• Ankylosing Spondylitis
• Celiac Disease
• Non-radiographic Axial Spondyloarthritis (Nr-axSpA)
• Crohn&Amp;#39;s Disease
• Birdshot Chorioretinitis

Interventions

Type	Name	Description
PROCEDURE	Companion blood samples with procedure	Participants in all cohorts will have a companion blood sample obtained on or around the time of the procedure intended to obtain tissue or fluid.

Timeline

• Start date: 2023-01-03
• Primary completion: 2027-01-01
• Completion: 2027-01-01
• First posted: 2024-09-19
• Last updated: 2025-11-24

Locations

12 sites across 1 country: United States