NCT06587763

Late Biomarkers in Adult Survivors After Out-of-hospital Cardiac Arrest

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 400 (estimated)
• Sponsor: Region Skane · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Blood samples are collected at six months follow-up from adult survivors after out-of-hospital cardiac arrest. Patients will be informed about the study and if they consent to participation, venous blood will be drawn by authorised medical personnel. Plasma, serum and PAX-RNA will be collected (ca 15 ml in total), processed and frozen for analysis after trial completion.

Detailed description

Blood samples are collected at six months follow-up from adult survivors after out-of-hospital cardiac arrest. Patients will be informed about the study and if they consent to participation, venous blood will be drawn by authorised medical personnel. Plasma, serum and PAX-RNA will be collected (ca 15 ml in total), processed and frozen for analysis after trial completion. Samples will be analysed in batch for biomarkers of brain injury, inflammation etc. Primary outcome is functional outcome (modified Rankin Scale 4-6) at six months after cardiac arrest. Secondary outcomes are neurocognitive function according to the Montreal Cognitive Assessment (MoCA), Symbol Digits Modalities Test (SDMT).

Conditions

• Cardiac Arrest, Out-Of-Hospital

Timeline

• Start date: 2025-10-01
• Primary completion: 2028-12-31
• Completion: 2032-12-31
• First posted: 2024-09-19
• Last updated: 2025-06-27

Locations

3 sites across 1 country: Sweden