NCT06587477

Testicular Function and Semen Quality in Male Childhood and Adolescent Cancer Survivors

Effect of Cancer Treatment on Testicular Function and Semen Quality in Male Childhood and Adolescent Cancer Survivors

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: The University of Hong Kong · Academic / Other
• Sex: Male
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Cancer treatment can affect the testicular function, including sperm and hormonal functions. The aim of this study is to assess the testicular function and semen quality in young men who recover from childhood and adolescent cancer in Hong Kong. This can provide more information for pre-treatment counselling as well as improve post treatment survivorship care. The testicular function will be compared to aged-matched controls from men attending the Family Planning Association for premarital check-up.

Detailed description

This is a cohort observational study. The target population for the trial will be men who have received chemotherapy and/ or radiotherapy for cancer diagnosed when they were \< 18 years old, currently \> 18 years old to 50 years old and cancer in remission for at least 2 years. The testicular function, including sperm and hormonal functions, will be compared with aged-matched controls from men attending the Family Planning Association for premarital check-up.

Conditions

• Cancer, Treatment-Related
• Late Effect
• Semen Analysis

Interventions

Type	Name	Description
OTHER	Hormonal profile	Blood for FSH, LH, testosterone
OTHER	Semen analysis	Semen analysis
OTHER	Questionnaire	The European Male Ageing Study (EMAS) questionnaire

Timeline

• Start date: 2023-01-16
• Primary completion: 2027-12-31
• Completion: 2028-06-30
• First posted: 2024-09-19
• Last updated: 2024-09-19

Locations

1 site across 1 country: China