NCT06584552

LaCE (Lactobacillus Paracasei LPB27 On Early Childhood Eczema)

Lactobacillus Paracasei LPB27 On Early Childhood Eczema

• Status: Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: The University of New South Wales · Academic / Other
• Sex: All
• Age: 3 Months – 3 Years
• Healthy volunteers: Not accepted

Summary

The LaCE study is a double-blind, randomised, placebo-controlled trial examining the effectiveness of the probiotic Lactobacillus paracasei LPB27 in treating eczema in young children.

Detailed description

Childhood eczema is a common and chronic, relapsing disease of the skin which affects up to 20% of the paediatric population. Eczema has significant impact on the quality of life of those affected. Its main symptoms are dry skin and intense itching. There is currently no cure for eczema but there are treatments that try to relieve symptoms. These commonly include topical moisturisers and topical corticosteroids. Although topical corticosteroids are effective in minimising symptoms, there is a prevailing and universal fear of using topical corticosteroids which is one of the main reasons for poor treatment compliance. There have been emerging interests in prevention and treatment of eczema through modulation of the gut microbiome. The gut microbiome is a key regulator for the immune system and there is evidence that the composition of gut microbiome may reduce allergies by driving maturation of the immune system. It was shown that people with eczema have different bacteria in their gut compared to people without eczema. Therefore, this study's hypothesis is that administration of oral probiotics will benefit young children with eczema by improving their gut microbiome and quality of life.

Conditions

• Eczema
• Allergy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Lactobacillus Paracasei LPB27	Probiotic
OTHER	Maltodextrin	Placebo

Timeline

• Start date: 2024-11-15
• Primary completion: 2026-03-01
• Completion: 2026-09-01
• First posted: 2024-09-05
• Last updated: 2025-06-03

Locations

1 site across 1 country: Australia