NCT06584188

The Effect of Anti-inflammatory Cryoagent on the Level of Postoperative Pain in Patients With Symptomatic Irreversible Pulpitis and Apical Periodontitis.

• Status: Not Yet Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

* The aim of this study is comparative between: 1. Intra-radicular cryotherapy using cold anti-inflammatory {ketorolac tromethamine at 2-5C}. 2. Intra-radicular final flush anti-inflammatory {ketorolac tromethamine at room temperature}. * In terms of: C. Level of post-operative pain {POP} using a visual analog scale {VAS}. D. Level of substance P in periapical fluid will be analyzed by enzyme-linked immunosorbent assay (ELISA) kit. Outcomes : * Primary outcomes: Level of Post-operative pain. * Secondary outcomes: Level of substance P expression

Conditions

• Postoperative Pain

Interventions

Type	Name	Description
DRUG	anti-inflammatory ketorolac tromethamine	* Intra- radicular anti-inflammatory {ketorolac tromethamine at room temperature}. * Intra- radicular cold anti-inflammatory {ketorolac tromethamine at 2-5C}.

Timeline

• Start date: 2026-04-11
• Primary completion: 2026-04-12
• Completion: 2026-04-30
• First posted: 2024-09-04
• Last updated: 2026-04-15

Locations

1 site across 1 country: Egypt