NCT06584123

Molecular Pituitary Imaging Using 18F-FET PET

Exploring the Potential for 18F-fluoro-ethyl-tyrosine (18F-FET) to Enable Wider Access to Molecular Imaging for Patients With Pituitary Adenomas (FET-pit-PET Study)

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: University of Cambridge · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

The goal of this single centre pilot study is to explore whether 18F-fluoro-ethyl-tyrosine PET (FET-PET) yields comparable findings to 11C-methionine PET (Met-PET) for the localisation of pituitary tumours.

Detailed description

Up to 20 patients with pituitary adenomas (PA) who have previously undergone 11C-methionine PET (Met-PET) as part of routine clinical care will undergo 18F-fluoroethyltyrosine PET (FET-PET). Patients with newly diagnosed PA or residual/recurrent pituitary tumours following previous treatment will be eligible for recruitment to the study. Quantitative and qualitative analyses will be performed to assess whether MET-PET and FET-PET yield comparable findings in patients with newly diagnosed or recurrent PA.

Conditions

• Pituitary Adenoma

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	18F-Fluoro-ethyl-tyrosine (FET) PET	18F-Fluoro-ethyl-tyrosine PET study of the pituitary

Timeline

• Start date: 2024-09-03
• Primary completion: 2026-09-02
• Completion: 2026-12-31
• First posted: 2024-09-04
• Last updated: 2026-01-06

Locations

1 site across 1 country: United Kingdom