NCT06583863

Parasitic Infections and Ulcerative Colitis: Combining Anti-parasitic and Immunomodulatory Treatments May Achieve Remission

Parasitic Infection Flares up the Activity of Ulcerative Colitis; However, Combined Immunomodulatory Therapy With Anti-parasitic Treatment Could Proceed Toward Remission

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Benha University · Academic / Other
• Sex: All
• Age: 20 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The study aimed to explore the link between parasitic infections and the severity of ulcerative colitis (UC). 120 UC patients were divided into three groups: those without infection, those with Giardia lamblia infection treated with metronidazole, and those with Giardia infection treated with a combination of metronidazole and E. purpurea. The results revealed that patients with Giardia infections exhibited more severe UC symptoms. All groups experienced improved symptoms following treatment, but the combination therapy group demonstrated the most significant improvement. Remission rates were highest in the group without infection and the group receiving combination therapy. Additionally, the study identified E. purpurea therapy and a substantial reduction in SCCAI score as significant predictors of higher remission rates.

Conditions

• Ulcerative Colitis

Interventions

Type	Name	Description
DRUG	Echinacea Extract	175 mg of Echinacea extract was provided as an immunlant therapy twice daily.
DRUG	MetroNIDAZOLE 500 MG Oral Tablet [Flagyl]	500 mg of metronidazole was provided as an oral tablets twice daily

Timeline

• Start date: 2023-09-12
• Primary completion: 2024-04-01
• Completion: 2024-06-12
• First posted: 2024-09-04
• Last updated: 2024-09-04

Locations

1 site across 1 country: Egypt