NCT06581887

Defining Outcome Measures for Behavioural and Emotional Problems in Dystrophinopathies

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 100 (estimated)
• Sponsor: University College, London · Academic / Other
• Sex: Male
• Age: 7 Years – 17 Years
• Healthy volunteers: Accepted

Summary

Study aims to develop and to evaluate the neurophysiological and physiological response to a classical conditioning task.To better understand how Duchenne Muscular Dystrophy (DMD) and Becker Muscular Dystrophy (BMD) impacts mental health and how to assess it. Participants invited to complete questionnaires about behaviour, cognitive function and social interactions, complete computer tasks and have an optional MRI brain scan,

Detailed description

The investigation aims to develop and to evaluate the neurophysiological and physiological response to a classical conditioning task, which is comparable to findings that have been made in the mdx dystrophic mouse (deficient in Dp427). The investigators will assess correlations between the specific DMD/BMD genotype and susceptibility to conditioning, as well as the relationship between conditioning and behavioural/emotional characteristics of the syndrome. At the end of the study, the objective is to deliver a comprehensive test battery that is suitable for use in a trial of AON delivery to improve brain function.

Conditions

• DMD
• BMD

Interventions

Type	Name	Description
BEHAVIORAL	Classical conditioning task	To evaluate the neurophysiological and physiological response to a classical conditioning task, which is comparable to findings that have been made in the mdx dystrophic mouse (deficient in Dp427). The investigators will assess correlations between the specific DMD/BMD genotype and susceptibility to conditioning, as well as the relationship between conditioning and behavioural/emotional characteristics of the syndrome.

Timeline

• Start date: 2022-09-13
• Primary completion: 2024-11-19
• Completion: 2024-12-31
• First posted: 2024-09-03
• Last updated: 2024-09-03

Locations

1 site across 1 country: United Kingdom